Step	Pathway	KO	FRH46_2	FRH46_3	FRH46_4	FRH46_5	FRH46_6	FRH47_2	FRH47_3	FRH47_4	FRH47_5	FRH47_6	FRH48_2	FRH48_3	FRH48_4	FRH48_5	FRH48_6	FRH49_3	FRH49_4	FRH49_5	FRH49_6	FRH50_3	FRH50_4	FRH50_5	FRH50_6	FRH51_2	FRH51_3	FRH51_4	FRH51_5	FRH51_6	FRH52_2	FRH52_3	FRH52_4	FRH52_5	FRH52_6	FRH53_2	FRH53_3	FRH53_4	FRH53_5	FRH53_6	FRH54_2	FRH54_3	FRH54_4	FRH54_5	FRH54_6	FRH55_2	FRH55_3	FRH55_4	FRH55_5	FRH55_6	FRH56_2	FRH56_3	FRH56_4	FRH56_5	FRH56_6	FRH57_3	FRH57_4	FRH57_5	FRH57_6
Sulfate to APS	Assimilatory sulfate reduction	K00958	20	4	9	11	12	4	24	36	55	48	10	5	6	7	30	9	6	20	25	5	19	72	50	6	2	4	6	6	0	12	26	24	40	3	19	19	47	63	9	0	26	1	2	1	1	4	8	38	4	0	14	0	7	39	18	47	67
Sulfate to APS	Assimilatory sulfate reduction	K00955	24	15	33	16	53	12	86	156	184	144	12	5	13	36	123	46	42	77	62	46	87	195	158	10	11	11	17	23	0	23	25	46	63	2	48	78	158	160	7	2	22	6	6	6	6	7	19	95	10	2	28	0	12	73	56	129	161
APS to PAPS	Assimilatory sulfate reduction	K00955	24	15	33	16	53	12	86	156	184	144	12	5	13	36	123	46	42	77	62	46	87	195	158	10	11	11	17	23	0	23	25	46	63	2	48	78	158	160	7	2	22	6	6	6	6	7	19	95	10	2	28	0	12	73	56	129	161
PAPS to Sulfite	Assimilatory sulfate reduction	K00390	73	18	42	45	71	33	155	263	335	247	31	26	34	78	209	68	56	104	90	64	143	322	249	18	24	24	35	46	1	52	60	96	131	9	92	134	272	291	36	4	106	14	18	10	9	16	38	181	31	5	65	3	32	138	97	235	325
Sulfite to Sulfide	Assimilatory sulfate reduction	K00380	20	1	6	9	9	11	20	33	41	27	12	10	10	18	25	10	9	19	21	5	17	41	25	3	4	5	6	6	0	10	8	13	18	3	12	20	40	42	17	0	54	6	10	1	1	3	10	25	11	0	17	0	12	16	11	27	41
Sulfite to Sulfide	Assimilatory sulfate reduction	K00392	14	3	4	10	9	12	20	43	49	31	5	8	9	14	32	10	7	5	6	10	24	45	17	4	9	8	8	12	1	11	14	20	24	1	24	25	41	62	7	3	14	2	3	2	3	5	6	27	13	4	15	2	9	23	15	31	51
Sulfate to APS	Dissimilatory sulfute reduction and oxidation	K00958	20	4	9	11	12	4	24	36	55	48	10	5	6	7	30	9	6	20	25	5	19	72	50	6	2	4	6	6	0	12	26	24	40	3	19	19	47	63	9	0	26	1	2	1	1	4	8	38	4	0	14	0	7	39	18	47	67
Sulfite to Sulfide	Dissimilatory sulfute reduction and oxidation	K11180	4	4	6	3	8	1	2	2	5	12	8	2	0	1	0	6	6	17	21	1	3	14	23	3	2	0	3	3	0	0	5	3	1	1	3	2	4	4	1	0	3	0	1	0	0	1	4	4	0	0	1	0	0	2	0	3	6
Thiosulfate to Sulfate	Sox System	K17222	12	1	2	6	10	3	8	22	23	18	3	0	1	4	14	7	5	7	6	8	14	33	17	0	1	2	4	5	0	5	9	12	17	1	6	8	22	20	1	0	6	0	3	1	0	1	6	18	3	0	8	0	3	15	7	18	27
Thiosulfate to Sulfate	Sox System	K17223	12	1	2	6	10	3	8	22	23	18	3	0	1	4	14	7	5	7	6	8	14	33	17	0	1	2	4	5	0	5	9	12	17	1	6	8	22	20	1	0	6	0	3	1	0	1	6	18	3	0	8	0	3	15	7	18	27
Thiosulfate to Sulfate	Sox System	K17226	25	5	11	13	24	6	33	68	84	70	5	3	5	20	48	23	17	32	26	22	43	103	72	5	6	5	10	15	0	11	11	27	39	1	23	34	72	69	3	0	11	1	4	4	1	3	13	63	4	0	15	0	9	44	23	57	76
Thiosulfate to Sulfate	Sox System	K17227	22	2	4	9	15	4	18	34	45	31	5	3	2	10	23	13	9	17	12	13	23	56	33	2	5	3	7	11	0	9	10	16	26	1	16	24	38	41	1	0	7	1	3	1	0	1	10	32	3	0	10	0	6	30	15	32	46
Thiosulfate to Sulfate	Sox System	K17224	10	1	1	6	8	2	8	17	20	14	3	0	1	4	12	5	3	4	4	5	9	28	13	0	1	2	3	2	0	5	8	10	16	1	6	8	19	19	1	0	6	0	2	1	0	1	5	16	3	0	7	0	2	13	5	14	23
SoxYZ-S-SH to Sulfate	Sox System	K17225	5	1	1	4	4	1	6	10	13	8	3	0	1	2	6	2	1	3	3	5	10	16	8	0	1	2	3	4	0	4	6	7	8	1	2	7	14	9	1	0	5	0	1	1	0	1	4	11	2	0	4	0	2	9	4	6	14
SoxYZ-S-SH to Sulfate	Sox System	K17224	10	1	1	6	8	2	8	17	20	14	3	0	1	4	12	5	3	4	4	5	9	28	13	0	1	2	3	2	0	5	8	10	16	1	6	8	19	19	1	0	6	0	2	1	0	1	5	16	3	0	7	0	2	13	5	14	23