Step	Pathway	KO	FRH46_2	FRH46_3	FRH46_4	FRH46_5	FRH46_6	FRH47_2	FRH47_3	FRH47_4	FRH47_5	FRH47_6	FRH48_2	FRH48_3	FRH48_4	FRH48_5	FRH48_6	FRH49_3	FRH49_4	FRH49_5	FRH49_6	FRH50_3	FRH50_4	FRH50_5	FRH50_6	FRH51_2	FRH51_3	FRH51_4	FRH51_5	FRH51_6	FRH52_2	FRH52_3	FRH52_4	FRH52_5	FRH52_6	FRH53_2	FRH53_3	FRH53_4	FRH53_5	FRH53_6	FRH54_2	FRH54_3	FRH54_4	FRH54_5	FRH54_6	FRH55_2	FRH55_3	FRH55_4	FRH55_5	FRH55_6	FRH56_2	FRH56_3	FRH56_4	FRH56_5	FRH56_6	FRH57_3	FRH57_4	FRH57_5	FRH57_6
Nitrogen to Ammonia	Nfixation	K02586	5	4	9	7	13	1	6	7	12	20	6	2	1	4	7	9	10	22	26	5	6	25	35	6	2	3	5	5	0	3	2	2	2	1	4	3	7	7	1	0	3	1	1	0	0	0	3	6	2	0	3	0	1	4	1	4	5
Nitrogen to Ammonia	Nfixation	K22896	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Nitrate to Nitrite	Nitrification	K00370	8	1	7	5	10	3	16	25	34	15	9	2	2	6	15	7	6	10	12	3	7	21	19	2	3	2	5	5	0	3	6	5	4	1	11	19	23	19	7	0	12	3	2	0	0	0	7	8	6	0	9	0	8	9	10	23	26
nitrite to hydroxylamine	Nitrification	K10535	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Hydroxlamine to ammonia	Nitrification	K10944	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	2	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0
Nitrate to Nitrite	Denitrification	K00370	8	1	7	5	10	3	16	25	34	15	9	2	2	6	15	7	6	10	12	3	7	21	19	2	3	2	5	5	0	3	6	5	4	1	11	19	23	19	7	0	12	3	2	0	0	0	7	8	6	0	9	0	8	9	10	23	26
Nitrate to Nitrite	Denitrification	K02567	11	2	4	4	4	5	9	17	18	18	2	1	1	5	10	6	3	8	8	2	4	15	20	3	3	1	2	2	0	5	7	4	8	2	10	7	14	9	6	0	23	4	5	3	2	5	7	13	2	1	10	0	5	5	3	9	14
Nitrite to Nitric Oxide	Denitrification	K00368	4	0	0	1	0	1	2	2	3	3	1	6	2	1	1	2	1	1	2	1	2	6	5	1	0	0	1	0	0	4	2	2	2	1	3	2	5	6	1	0	4	2	3	0	0	2	2	3	3	0	8	0	5	2	2	3	5
Nitrite to Nitric Oxide	Denitrification	K15864	5	0	0	1	0	1	1	2	2	1	1	0	0	2	1	0	0	0	0	0	0	2	0	1	0	0	0	0	0	0	4	2	3	1	2	3	2	1	2	0	3	0	1	0	0	1	2	1	0	0	1	0	2	2	1	2	5
Nitric Oxide to Nitrous oxide	Denitrification	K04561	11	2	6	3	5	3	10	20	20	21	3	3	2	6	10	6	4	15	17	2	6	20	31	2	1	1	1	2	0	2	4	6	9	3	6	7	18	9	4	0	8	4	4	2	1	2	5	20	3	1	10	0	7	8	6	13	21
Nitrous oxide to Nitrogen	Denitrification	K00376	10	1	1	4	2	2	8	20	27	23	3	2	1	7	12	6	3	6	6	4	9	20	21	3	2	2	3	4	0	3	6	5	11	1	7	8	13	16	4	0	5	0	2	2	1	3	5	19	2	1	8	0	4	9	6	17	35
Nitrite to Nitric Oxide	Anammox	K00368	4	0	0	1	0	1	2	2	3	3	1	6	2	1	1	2	1	1	2	1	2	6	5	1	0	0	1	0	0	4	2	2	2	1	3	2	5	6	1	0	4	2	3	0	0	2	2	3	3	0	8	0	5	2	2	3	5
Nitrite to Nitric Oxide	Anammox	K15864	5	0	0	1	0	1	1	2	2	1	1	0	0	2	1	0	0	0	0	0	0	2	0	1	0	0	0	0	0	0	4	2	3	1	2	3	2	1	2	0	3	0	1	0	0	1	2	1	0	0	1	0	2	2	1	2	5
Ammonia to Hydrazine	Anammox	K20932	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Hydrazine to Nitrogen	Anammox	K20935	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Nitrate to Nitrite	Assimilatory nitrate reduction	K00367	1	0	1	0	2	1	1	3	2	7	0	0	0	0	0	1	2	2	2	0	2	5	3	1	0	0	0	0	0	1	1	1	1	0	0	0	1	3	0	0	0	0	1	0	0	0	1	2	2	0	1	0	3	2	0	1	3
Nitrate to Nitrite	Assimilatory nitrate reduction	K10534	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Nitrate to Nitrite	Assimilatory nitrate reduction	K00372	18	4	10	13	15	11	32	48	60	39	11	8	14	11	36	14	9	14	14	12	31	65	36	3	6	6	6	6	0	16	11	14	17	2	15	22	33	39	18	0	50	9	10	1	2	5	9	35	10	1	17	0	9	15	13	28	43
Nitrite to Ammonia	Assimilatory nitrate reduction	K17877	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Nitrite to Ammonia	Assimilatory nitrate reduction	K00366	1	0	1	0	2	1	1	3	2	7	0	0	0	0	0	1	2	2	2	0	2	5	3	1	0	0	0	0	0	1	1	1	1	0	0	0	1	3	0	0	0	0	1	0	0	0	1	2	2	0	1	0	3	2	0	1	3
Nitrate to NItrite	Dissimilatory nitrate reduction	K00370	8	1	7	5	10	3	16	25	34	15	9	2	2	6	15	7	6	10	12	3	7	21	19	2	3	2	5	5	0	3	6	5	4	1	11	19	23	19	7	0	12	3	2	0	0	0	7	8	6	0	9	0	8	9	10	23	26
Nitrate to NItrite	Dissimilatory nitrate reduction	K02567	11	2	4	4	4	5	9	17	18	18	2	1	1	5	10	6	3	8	8	2	4	15	20	3	3	1	2	2	0	5	7	4	8	2	10	7	14	9	6	0	23	4	5	3	2	5	7	13	2	1	10	0	5	5	3	9	14
Nitrite to Ammonia	Dissimilatory nitrate reduction	K00362	29	8	18	17	20	17	41	58	79	54	20	13	20	20	48	19	14	27	26	15	39	75	52	7	8	8	7	7	1	20	22	20	24	3	24	32	51	52	24	1	66	10	11	2	3	8	14	51	18	4	22	3	15	25	16	42	59
Nitrite to Ammonia	Dissimilatory nitrate reduction	K03385	4	2	5	3	6	4	6	10	13	21	2	4	2	2	4	3	6	15	19	2	3	23	33	3	2	1	2	1	0	3	3	4	6	0	7	4	8	8	5	1	14	4	7	1	2	3	5	10	3	0	6	2	3	3	2	7	11