edme.v1.1.zip (2.78 MB)

Effect Direction MEta-analysis (EDME) of GWAS

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posted on 06.02.2020 by RUIDONG XIANG
EDME conducts Effect Direction MEta-analysis of GWAS for the same traits generated from two independent populations. The principle is to use the agreement of GWAS signs (+ or - for the same trait in two populations) to identify true signals from GWAS. It can be applied to single-trait and multi-trait analysis. The tutorial which shows how to use this software is at: https://ruidongxiang.com/effect-direction-meta-analysis-edme-of-gwas/.


Xiang et al (2020). Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal. Communications Biology (In Press).


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