Finite element results (archive): high RyR density, with mitochondria
David Ladd
10.26188/5cd127480b8f7
https://melbourne.figshare.com/articles/Finite_element_results_archive_high_RyR_density_with_mitochondria/8067464
Results from a reaction-diffusion finite element model of calcium signalling in a rat ventricular cardiomyocyte. Solved for the first 30 ms of the calcium transient in an 8 sarcomere section.<div><br></div><div>Calcium is released from RyR clusters with spacings based on immuno-labeled microscopy data populations (123 clusters per z-disk). Regions representing mitochondria are excluded to produce barriers to diffusion in the intracellular space.</div><div><br></div><div>To view the results of the calcium and fluorescence-bound calcium fields, visualisation of the results in the 'vtk' folder with ParaView is recommended. All field data is available in OpenCMISS exnode / exelem formats in the 'output' folder. Note this model was run on 8 parallel processes.</div>
2019-05-07 06:35:50
calcium signalling
cardiomyocyte
reaction-diffusion
Finite element modelling
excitation-contraction coupling