10.26188/5cd1275a2d54d
David Ladd
Finite element results (archive): low RyR density, with mitochondria
2019
University of Melbourne
calcium signalling
cardiomyocyte
reaction-diffusion
Finite element modelling
excitation-contraction coupling
2019-05-07 06:35:50
article
https://melbourne.figshare.com/articles/Finite_element_results_archive_low_RyR_density_with_mitochondria/8067404
Results from a reaction-diffusion finite element model of calcium signalling in a rat ventricular cardiomyocyte. Solved for the first 30 ms of the calcium transient in an 8 sarcomere section.<div><br></div><div>Calcium is released from RyR clusters with a minimum 1um spacing between them (50 clusters per z-disk). Regions representing mitochondria are excluded to produce barriers to diffusion in the intracellular space.</div><div><br></div><div>To view the results of the calcium and fluorescence-bound calcium fields, visualisation of the results in the 'vtk' folder with ParaView is recommended. All field data is available in OpenCMISS exnode / exelem formats in the 'output' folder. Note this model was run on 4 parallel processes. </div>